When Paul arrived in Ephesus, he wrote to the saints in 1 Corinthians 16:9, “There is a wide-open door for a great work here, although many oppose me.” Paul chose to think primarily about the "great open door", and not the “nay-sayers”.
Great opportunities are often accompanied by great opposition. The easiest thing to do when confronted with difficulty is to give up. When you begin to walk in that great open door it is crucial to keep going, no matter what is in the way, no matter what threatens to prevent you from doing God’s will.
The most fascinating thing about the opposition you encounter when you walk through those open doors of opportunity, is that the criticism, the anger, the ridicule, the questioning, the sarcasm, the treachery, the threats, the name calling, the backbiting, the curses, the doubting, of not only your abilities, but your calling and anointing, is that all these things are prompted by your progress, which often occurs when God’s people start to make things happen.
When God opens up the great door of opportunity, and you began to walk through that door, what you have just done is walked straight into the center of His Will.